Chinese Skullcap is antiviral and protects mitochondria from viral damage. In addition to anti-aggregation properties of baicalein, there is also a lot of research suggesting that it has beneficial effects in other non-alpha synuclein models of Parkinson’s, such as those involving classical neurotoxins: Title: Baicalein prevents 6-OHDA/ascorbic acid-induced calcium-dependent dopaminergic neuronal cell death. One of the compounds, an alkaloid called isorhy, induced autophagy for alpha-synuclein at a similar rate to a drug called rapamycin. Baikal skullcap belongs to the same family of flowering plants (Lamiaceae) as thyme, basil, mint and rosemary. Kind regards, Chinese skullcap helps in memory and cognitive improvements with its neuroprotective action and several studies are carried out for proving this point. Once upon a thyme, in a far away land, there was a mysterious little flowering plant. However, because rapamycin depresses the immune system, it would have serious side effects for people with Parkinson’s. Hi Alan, Skullcap is most often used as a sleep … Authors: Hong D-P, Fink AL, Uversky VN Anxiety Relief. It suppresses viral growth in the body while also reducing inflammation. In this study, the researchers found that baicalein can actually induce the formation of the alpha synuclein oligomers but it prevents the production of fibrils – even after very prolonged incubations. It’s primary use is to clear heat or roughly, in western terms, inflamation and phlegm. What is Baikal skullcap? Hence, the ‘750,000 compound study’ mentioned above (in which 5 biotech companies participated). Stress management can help symptoms, but there is no effective medicine to treat it. Li’s team screened gou teng for its active compounds and tested which of these compounds increase the rate of autophagy and remove alpha-synuclein. Any actions being contemplated by readers should firstly be discussed with a qualified healthcare professional who is aware of your medical history. Research on rats has discovered that Chinese skullcap can prevent the development of benign prostatic hyperplasia (BPH) by suppressing abnormal androgen and relieving inflammation. This raises the question of how much of the drug is getting to the brain. Scutellaria baicalensis is used in traditional medicine to treat many medical conditions, but studies in humans are limited. Science with Sam explains. Kind regards, The plant grows to between 1-4 feet in height, with lance head-shaped leaves and blue-purple flowers. Authors: Zhu M, Rajamani S, Kaylor J, Han S, Zhou F, Fink AL. ( Log Out /  Chinese skullcap has been used to help treat a large number of conditions and has been shown to be a useful anti-inflammatory. In the affected areas of the Parkinsonian brain, aggregated alpha synuclein can be seen in the branches (or neurites; see black arrow in the image below) of cells. In the image below, alpha synuclein has been stained brown on a section of brain from a person with Parkinson’s. I strongly advise you not to use it as a supplement. Scutellaria galericulata. Baicalein was found to hit a peak dose approximately 1-3 hours post administration and it lasted up to 15 hours in the body. While baicalein is generally considered safe (based on the limited amount of information we have), there are some people eople who should avoid using baicalein. Analysis of the results indicate that a single oral dose of baicalein in the ranges tested was safe and well tolerated. They demonstrated that very low concentrations of baicalein – especially its oxidized forms – inhibited the formation of alpha synuclein fibrils. So they screened 750,000 other drugs to find something like Baicalein with a potential 50 billion dollar payday. According to Li, autophagy is the only known process that gets rid of abnormal proteins within cells. The dried roots have been used for hundreds of years as a traditional Chinese medicine called Huang Qin used for the treatment of insomnia, diarrhoea, dysentery, … Both have benefits, but the Chinese herb is the main focus of this post. But because these compounds have a long history of being safe for human consumption, it is hoped they will be approved faster, says Li. Baicalein begins life as baicalin. 2008 Oct 31;383(1):214-23. Baicalein a type of flavonoid – a diverse group of nutrients found in almost all fruits and vegetables. They are important for plants in that they are pigments for flower coloration, producing yellow or red/blue pigmentations in flowers which help to attract pollinating insects. And one is left questioning why it hasn’t warranted more. Baicalein a natural product so no payday for Baicalein. Samples of blood, urine and feces were collected at regular intervals until 48 h post treatment. Journal: Sci Rep. 2017 Aug 21;7(1):8398. doi: 10.1038/s41598-017-07142-7. Just be sure to consult with your clinician/neurologist before changing any current treatment regime to avoid any potential contraindications or side effects etc. If you have diabetes, DO NOT take Chinese skullcap without your doctor's supervision. Baikal skullcap. ( Log Out /  Now, Li and her colleagues have figured out how it might work. When it is first produced, alpha synuclein will look something like this: In this form, alpha synuclein is considered a monomer – which is a single molecule that can bind to other molecules. S. baicalensis, also known as Huang Qin or Chinese skullcap, is a root extract used in traditional medicine.It is often used in combination with other herbs. A cartoon of a neuron, with the Lewy body indicated within the cell body. Authors: Li M, Shi A, Pang H, Xue W, Li Y, Cao G, Yan B, Dong F, Li K, Xiao W, He G, Du G, Hu X. Ok, but why are we talking about baicalein? Prevent Parkinson’s disease. His team has since isolated several active compounds in JCM-16021 that block serotonin’s activity in the rat gut, including magnolol, a herb taken from the bark of Magnoliae officinalis. The above ground parts are used to make medicine. Obviously some, given the preclinical experiments on models of Parkinson’s and Alzheimer’s, but it would be useful to know this detail in humans. A Chinese team of researchers now investigated the effects of baicalin on a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson’s disease. There are two main types of skullcap. So baicalein is known to reduce alpha synuclein aggregation? Given the potent effect baicalein had on beta amyloid aggregates, the investigators were keen to determine if this compound would also influence alpha synuclein aggregates. Baicalin (the pre-cursor to baicalein that we discussed near the top of the post) is more plentiful and it is easily converted into baicalein once consumed. And of those nine compounds were prioritised for further analysis. Specifically, the investigators wanted to determine which compounds could reduce the aggregation of alpha synuclein. Several eagle-eyed readers, however, noted something interesting in the details of one of the research reports that was discussed in that post. And the investigators concluded that “the targeted stabilisation of certain alpha synuclein oligomers might offer a potential strategy for the development of novel Parkinson’s disease therapies”. Parkinson’s symptoms, such as muscle tremors, slowness of movement and rigidity, are caused by the progressive destruction of brain cells that produce dopamine. More research is required before recommending skullcap in humans. 4. The plant grows to about 1-4 ft. tall, with … Any actions taken – based on what has been read on the website – are the sole responsibility of the reader. Nor is it taken as a single herb. IBS affects up to 20 per cent of people, causing abdominal pain, constipation and diarrhoea. In addition to being found in the roots of Baical skullcap, baicalein is also found in the leaves of the herbs thyme, mad-dog skullcap, and the midnight horror or broken bones plant. PMID: 15096521                     (This report is OPEN ACCESS if you would like to read it). Source: Gobotany. Microscopic images of Monomers, oligomers and fibrils. Anti-inflammatory agent : Skullcap tincture is highly effective against diseases like inflammatory bowel syndrome, rheumatoid arthritis, ulcers and more. Baikal skullcap is a Chinese medicinal herb that was used for over 2,000 years to treat fevers, hypertension, coughing, and other ailments, and is used today as a traditional remedy for … Under no circumstances should it ever be considered medical or actionable advice. It is provided by research scientists, not medical practitioners. Source: Brain. Seems promising if it doesn’t affect one’s other meds. Overview Information Skullcap is a plant. And one of the key constituents of Baikal skullcap (and huángqín) is a compound called baicalein. Most studies have been done in the … Laboratory investigations indicate no signs of toxicity in the liver or kidney. Simon, Simon Very interesting post. is it the Chinese Scutellaria galericulata you are taking or the native American medinal Scutellaria lateriflora? 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